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Smoking Cessation clinical trials

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NCT ID: NCT05539209 Recruiting - Smoking Cessation Clinical Trials

Testing a Novel Smartphone Application for Smoking Cessation With the Oklahoma Helpline

OKquit
Start date: September 13, 2022
Phase: N/A
Study type: Interventional

Over 470,000 tobacco users have been served by the Oklahoma Tobacco Helpline (OTH). The OTH reaches a substantial number of smokers each year, but follow-up rates are notoriously low and many smokers may prefer smartphone-based smoking cessation interventions rather than web- or phone-based OTH programming (e.g., counseling). Highly flexible and low burden technology-based treatment approaches may overcome barriers that have limited the use and effectiveness of traditional smoking cessation treatments among underserved adult smokers (e.g., racial/ethnic minorities, rural residence, low socioeconomic status). This study is a randomized controlled trial that will evaluate the feasibility and initial efficacy of an innovative, evidence-based smoking cessation app tailored for smokers that contact the OTH for services. A total of 500 treatment-seeking men and women will be randomly assigned to receive either Standard Helpline Care plus brief (30 second) daily check-ins and weekly smartphone-based surveys through the Insight app (SC) or SC plus the OKquit smoking cessation app (OKq). All participants will receive standard Helpline services (e.g., nicotine replacement therapy), but only the OKq group will receive on-demand content and tailored messages through the app. All participants will be followed for 27 weeks after they are randomized to an intervention group and complete smartphone-based survey assessments. Participants that report smoking abstinence during the 26-week EMA will be sent a low-cost carbon monoxide monitor to verify smoking status.

NCT ID: NCT05515354 Recruiting - Smoking Cessation Clinical Trials

Smoking Cessation and Menstrual Cycle Phase

MC-NRT
Start date: November 30, 2022
Phase: Phase 4
Study type: Interventional

Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women who currently smoke. However, findings from controlled trials and real-world clinical settings indicate that women have greater difficulty achieving abstinence following a quit attempt than men. There is some evidence that hormonal levels and fluctuations throughout the menstrual cycle (MC) may contribute to the greater difficulty women experience when trying to quit smoking. In this study, the start of a quit attempt using nicotine replacement therapy (NRT) will be targeted to specific phases of MC. It was hypothesized that starting a quit attempt during the first half of MC (follicular phase) will result in increased quit success compared to starting during the second half of MC (luteal phase) or the usual practice of not targeting quit start date to MC phase.

NCT ID: NCT05513872 Recruiting - Smoking Cessation Clinical Trials

Overcoming Nicotine Dependence to Enable Quitting

ON-DEQ
Start date: February 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.

NCT ID: NCT05493254 Recruiting - Smoking Cessation Clinical Trials

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

E-STOP
Start date: August 31, 2022
Phase: N/A
Study type: Interventional

The purpose of this research study is to evaluate an electronic visit (e-visit) for smoking cessation. Participants will be randomly assigned to receive either the smoking cessation e-visit or not. The e-visit will look similar to an online questionnaire asking about smoking history, motivation to quit, and preferences for medications for quitting smoking. Participants may receive a prescription for a smoking cessation medication as an outcome of the e-visit, if randomized to the e-visit group, but there is no requirement to take any medication. This study consists of questionnaires and breath samples provided at 4 separate time points throughout the study. Participation in this study will take about 24 weeks.

NCT ID: NCT05490251 Recruiting - Smoking Cessation Clinical Trials

Translational Research Center in Lung Cancer Disparities (TRACER) Project 2

TRACER
Start date: June 1, 2024
Phase:
Study type: Observational

The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.

NCT ID: NCT05460676 Recruiting - Smoking Cessation Clinical Trials

Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study

Start date: August 15, 2023
Phase: N/A
Study type: Interventional

The study aims to evaluate the feasibility of using Dorsolateral Prefrontal Cortex (DLPFC) Transcranial Direct Current Stimulation (tDCS) as a tool to decreasing distress and cigarette smoking. 46 participants currently smoking cigarettes, and seeking to decrease cigarette use will be recruited.

NCT ID: NCT05430789 Recruiting - Smoking Cessation Clinical Trials

Post-discharge Cessation for Smoking Patients

Start date: June 24, 2022
Phase: N/A
Study type: Interventional

This study aims to enhance the general 5As brief advice model with interactive mobile phone-based intervention and active referral to community smoking cessation services for smoking patients discharged from hospitals.

NCT ID: NCT05413122 Recruiting - HIV Clinical Trials

Evaluating Smoking Cessation Interventions for PWH in South Africa

Tlogela
Start date: November 27, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.

NCT ID: NCT05370352 Recruiting - Smoking Cessation Clinical Trials

Mobile Chat Messaging for Smoking Relapse Prevention

Start date: March 14, 2023
Phase: N/A
Study type: Interventional

Most smokers return to smoking (relapse) after making a quit attempt, but evidence of effective intervention to prevent relapse is scarce. Taking advantage of recent advances in mobile technologies, this study aims to evaluate the effectiveness of a mobile chat messaging-based relapse prevention intervention in promoting successful quitting in people who recently quit smoking (recent abstainers) using a randomised controlled trial design.

NCT ID: NCT05355012 Recruiting - Smoking Cessation Clinical Trials

Organization of Smoking Cessation in Pregnant Women With the Implementation of the 5A Strategy in New Aquitaine.

5A-QUIT-N
Start date: October 3, 2022
Phase: N/A
Study type: Interventional

The investigators are conducting a pragmatic cluster randomized trial in stepped-wedge of which objectives are to evaluate the effectiveness and the conditions of effectiveness of an organizational strategy for smoking cessation - 5A-QUIT-N - among pregnant women in New Aquitaine (NA), by using and optimizing existing resources