Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether prazosin will:

- reduce the incidence of nightmares and sleep disturbance

- increase functioning and sense of well being in combat-trauma exposed Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Veterans.

Clinical Trial Description

This is a 15-week randomized parallel design, double-blind, placebo-controlled augmentation trial of prazosin to evaluate the efficacy and tolerability of prazosin augmentation in the treatment of PTSD trauma-related nightmares, sleep disturbance, global function and sense of well-being, and other clinical features and comorbidities of PTSD. Participants will be 210 OIF/OEF soldiers and veterans who have suffered war zone trauma. Participants will be randomized 1:1 to prazosin or placebo and all previous psychotropic medications and/or psychotherapy will be maintained constant. Randomization will be stratified by site and use of an antidepressant. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00990106
Study type	Interventional
Source	Seattle Institute for Biomedical and Clinical Research
Contact
Status	Completed
Phase	N/A
Start date	September 2009
Completion date	March 2013

View Details

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