Clinical Trials Logo
  1. Home
  2. Sleep Apnea Syndromes
  3. NCT01457014

Sleep Disordered Breathing and Chronic Pain

Sleep Apnea Syndromes Clinical Trial

Official title:
BiPAP Adaptive Servo-Ventilation (AutoSV) Therapy in Patients With Chronic Pain and Sleep Disordered Breathing (SDB)

Clinical Trial Summary

The purpose of this study is to evaluate positive pressure in patients with chronic pain taking opioid medications who have sleep disordered breathing.

Clinical Trial Description

Purpose: Opioid treatment of non-malignant chronic pain can result in hypoxemia, hypercarbia, and central sleep apnea. The aim of this study was to determine the initial efficacy of auto servo-ventilation (ASV) and after 3 months of home use.

Methods: This prospective multicenter interventional study recruited chronic pain patients prescribed ≥100 morphine equivalents for at least 4 months.

Participants: Following full-night polysomnography (PSG) to confirm the presence of sleep-disordered breathing, patients were randomized to three additional full-night-attended PSGs with continuous positive airway pressure (CPAP), ASV, and servo-ventilation with an initial mandatory pressure support of 6 cm water (H2O) ASV manual Minimum Pressure Support (PSmin). Following the PSGs, patients were sent home with EncoreAnywhere and ASV with or without mandatory pressure support. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01457014
Study type Interventional
Source Philips Respironics
Contact
Status Completed
Phase N/A
Start date September 2011
Completion date September 2013
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05477719 - Effect of Compression Stockings on the Number of Apneas/Hypopneas Per Hour of Sleep in Patients With Syndrome Obstructive Sleep Apnea/Hypopnea as Compared to no Treatment N/A
Completed NCT04979234 - A Single Centre, Prospective Feasibility Study to Evaluate the Efficacy of an Endoluminal-suturing Device (Endomina) on Severe Obstructive Sleep Apnea Syndrome N/A
Terminated NCT02735694 - Cycloserine in the Treatment of Sleep Apnea Phase 1
Active, not recruiting NCT02470182 - Screening for Sleep Disordered Breathing With Minimally Obtrusive Sensors
Completed NCT02088723 - Testing the Elevation as Sleep Apnea Treatment N/A
Completed NCT00860743 - Respiratory and Autonomic Plasticity Following Intermittent Hypoxia Early Phase 1
Completed NCT00976417 - Mechanisms of Action of Adaptive Servoventilation N/A
Active, not recruiting NCT00371293 - The Effects of Obesity and Obstructive Sleep Apnea on Inflammation and Heart Disease N/A
Completed NCT00607893 - Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea N/A
Completed NCT00083798 - Family Linkage Study of Obstructive Sleep Apnea (OSA) in Iceland N/A
Completed NCT00089752 - Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea N/A
Completed NCT00070681 - Outcomes of Sleep Disorders in Older Men Phase 3
Completed NCT00051363 - Apnea Positive Pressure Long-Term Efficacy Study Phase 3
Completed NCT00046670 - Sleep Disordered Breathing, APOE, and Lipid Metabolism N/A
Completed NCT00031239 - Sleep Apnea in Look AHEAD Participants - Ancillary to Look AHEAD N/A
Terminated NCT00006321 - Neurocognitive Function in Snoring Children N/A
Completed NCT00006323 - Neurobehavioral Consequences of Sleep Apnea in Children N/A
Completed NCT00005511 - SCOR in Neurobiology of Sleep--Intermediate Traits for Sleep Apnea N/A
Completed NCT00005275 - Sleep Heart Health Study (SHHS) Data Coordinating Center N/A
Completed NCT00005320 - Regulation of Pharyngeal Muscle Contraction - SCOR in Cardiopulmonary Disorders of Sleep N/A