Sleep Apnea Syndrome Clinical Trial
Official title:
Effect of Obstructive Sleep Apnea Syndrome Associated With Obesity on Cough Reflex Threshold to Citric Acid
Up to 70% of obese patients undergoing bariatric surgery have obstructive sleep apnea syndrome (OSAS). OSAS is responsible for laryngeal sensory impairment. As the afferent neural pathway involved in the initiation of cough is located in the laryngeal epithelium, cough reflex sensitivity may be decreased in obese OSAS patients. The researchers therefore conducted this study to determine the effect of OSAS associated with obesity on cough reflex sensitivity, assessed by cough reflex threshold to an inhaled irritant (citric acid).
Obese patients undergoing scheduled bariatric surgery underwent a cough challenge as part of their routine preoperative evaluation. Patients were classified as presenting OSAS if apnea-hypopnea index obtained from preoperative full-night polysomnography was greater than 5/hour. Cough threshold was measured with citric acid. Increasing concentrations of mouth- nebulized citric acid (2.5, 5, 10, 20, 40, 80, 160, 320 and 640 mg/mL) were delivered during inspiration until a cough was elicited. The citric acid concentration eliciting one cough (C1) was defined as the cough reflex threshold. ;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02916160 -
Sacubitril-valsartan and Heart Failure Patients : the ENTRESTO-SAS Study
|
Phase 4 | |
Active, not recruiting |
NCT00746928 -
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
|
N/A | |
Terminated |
NCT00816829 -
Effect of Fenofibrate on Sleep Apnea Syndrome
|
Phase 2 | |
Recruiting |
NCT00152711 -
Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis
|
N/A | |
Completed |
NCT02482480 -
Comprehensive Management for the Treatment of Obstructive Sleep Apnea
|
N/A | |
Recruiting |
NCT02408172 -
Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome
|
Phase 2/Phase 3 | |
Terminated |
NCT01354756 -
Validation of Apnea LinkTM for Sleep Apnea Syndrome Screening in a Bariatric Population
|
N/A | |
Terminated |
NCT01196845 -
Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
|
N/A | |
Completed |
NCT03116958 -
MyOSA : Management and Treatment of Patients With Obstructive Sleep Apnea Syndrome(OSAS) Through a Telemedicine System
|
N/A | |
Terminated |
NCT02649933 -
Detection of Sleep Apnea Syndrome (OSA) in Pregnant Women and Assessment of Impact of OSA on Pregnancy Course
|
N/A | |
Completed |
NCT02789696 -
Prevalence of Acromegaly in a Diagnostic Consultation for Sleep Apnea Syndrome
|
N/A | |
Completed |
NCT01164631 -
Pharyngeal Size in Patients With Obstructive Tonsils Under Orthodontic Treatment
|
Phase 4 | |
Completed |
NCT02893865 -
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
|
N/A | |
Completed |
NCT02234765 -
Management of Patients With Suspected of Sleep Apnea-hypopnea Syndrome From Primary Care
|
N/A | |
Completed |
NCT01752556 -
Cost-effectiveness of Home Respiratory Polygraphy
|
Phase 3 | |
Completed |
NCT00001723 -
Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases
|
Phase 2 | |
Completed |
NCT02148432 -
Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome
|
N/A | |
Completed |
NCT02657304 -
Effect of Early Education on the Observance of CPAP Treatment
|
N/A | |
Completed |
NCT02591979 -
PASHOS Project: Advanced Platform for Sleep Apnea Syndrome Assessment
|
||
Recruiting |
NCT00936273 -
Sleep Apnea and Periodic Breathing
|
N/A |