Clinical Trials Logo

Clinical Trial Summary

Up to 70% of obese patients undergoing bariatric surgery have obstructive sleep apnea syndrome (OSAS). OSAS is responsible for laryngeal sensory impairment. As the afferent neural pathway involved in the initiation of cough is located in the laryngeal epithelium, cough reflex sensitivity may be decreased in obese OSAS patients. The researchers therefore conducted this study to determine the effect of OSAS associated with obesity on cough reflex sensitivity, assessed by cough reflex threshold to an inhaled irritant (citric acid).


Clinical Trial Description

Obese patients undergoing scheduled bariatric surgery underwent a cough challenge as part of their routine preoperative evaluation. Patients were classified as presenting OSAS if apnea-hypopnea index obtained from preoperative full-night polysomnography was greater than 5/hour. Cough threshold was measured with citric acid. Increasing concentrations of mouth- nebulized citric acid (2.5, 5, 10, 20, 40, 80, 160, 320 and 640 mg/mL) were delivered during inspiration until a cough was elicited. The citric acid concentration eliciting one cough (C1) was defined as the cough reflex threshold. ;


Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic


Related Conditions & MeSH terms


NCT number NCT00317083
Study type Interventional
Source Bichat Hospital
Contact
Status Completed
Phase N/A
Start date November 2001
Completion date February 2003

See also
  Status Clinical Trial Phase
Completed NCT02916160 - Sacubitril-valsartan and Heart Failure Patients : the ENTRESTO-SAS Study Phase 4
Active, not recruiting NCT00746928 - Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects N/A
Terminated NCT00816829 - Effect of Fenofibrate on Sleep Apnea Syndrome Phase 2
Recruiting NCT00152711 - Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis N/A
Completed NCT02482480 - Comprehensive Management for the Treatment of Obstructive Sleep Apnea N/A
Recruiting NCT02408172 - Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Phase 2/Phase 3
Terminated NCT01354756 - Validation of Apnea LinkTM for Sleep Apnea Syndrome Screening in a Bariatric Population N/A
Terminated NCT01196845 - Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome N/A
Completed NCT03116958 - MyOSA : Management and Treatment of Patients With Obstructive Sleep Apnea Syndrome(OSAS) Through a Telemedicine System N/A
Terminated NCT02649933 - Detection of Sleep Apnea Syndrome (OSA) in Pregnant Women and Assessment of Impact of OSA on Pregnancy Course N/A
Completed NCT02789696 - Prevalence of Acromegaly in a Diagnostic Consultation for Sleep Apnea Syndrome N/A
Completed NCT01164631 - Pharyngeal Size in Patients With Obstructive Tonsils Under Orthodontic Treatment Phase 4
Completed NCT02893865 - Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure N/A
Completed NCT02234765 - Management of Patients With Suspected of Sleep Apnea-hypopnea Syndrome From Primary Care N/A
Completed NCT01752556 - Cost-effectiveness of Home Respiratory Polygraphy Phase 3
Completed NCT00001723 - Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases Phase 2
Completed NCT02148432 - Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome N/A
Completed NCT02657304 - Effect of Early Education on the Observance of CPAP Treatment N/A
Completed NCT02591979 - PASHOS Project: Advanced Platform for Sleep Apnea Syndrome Assessment
Recruiting NCT00936273 - Sleep Apnea and Periodic Breathing N/A