Atherosclerosis Clinical Trial
Official title:
Premature Atherosclerosis in Systemic Lupus Erythematosus: a Prospective Cohort Study
Patients with SLE have increased rates of atherosclerosis, while the risk factors for atherosclerosis in those patients were not fully revealed. This study is an observational study to investigate the natural process and risk factors for atherosclerosis based on a Chinese SLE cohort. Carotid intima media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) will be measured for each patient at baseline and 5-year follow-up. Blood tests including cholesterol levels, fasting plasma glucose levels and etc. will also be performed.
Accelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE),
and it leads to increased cardiovascular morbidity and mortality in patients with SLE.
Prevention and intervention of premature atherosclerosis is beneficial for prognosis and
survival of patients with SLE.
The primary aim of this study was to investigate the natural progress of carotid intima media
thickness (CIMT) in 5 years, and examine the risk factors for progression of CIMT and
atherosclerotic plaques based on a Chinese SLE cohort. The secondary aims of the study were
to investigate progression of brachial-ankle pulse wave velocity (baPWV), and to examine the
risk factors for increasing baPWV in patients with SLE.
Based on sample size calculation, 440 patients who meet the eligibility criteria will be
enrolled in this study. All patients will be enrolled from Peking Union Medical College
Hospital. After informed consent is obtained, the patients will be comprehensively evaluated
from demographic characteristics, medical history, clinical assessments, laboratory tests
results, CIMT and baPWV at baseline and 5-year follow-up. Descriptive analysis, univariate
analysis, and multivariate analysis will be used to analyze the correlation between potential
risk factors and CIMT/baPWV.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05052918 -
The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
|
N/A | |
Recruiting |
NCT04511234 -
Sirolimus Coated Balloon Versus Standard Balloon for SFA and Popliteal Artery Disease
|
N/A | |
Completed |
NCT05906797 -
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
|
N/A | |
Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
Suspended |
NCT02932176 -
Machine Learning for Handheld Vascular Studies
|
||
Recruiting |
NCT05158257 -
Clinical Of Plain Balloon Dilatation Combined Stent Versus Endovascular Debulking Combined Drug-coated Balloon to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
|
N/A | |
Completed |
NCT01212900 -
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
|
Phase 4 | |
Completed |
NCT03697382 -
Effect of Daily Steps on Fat Metabolism
|
N/A | |
Recruiting |
NCT06230406 -
T-Mem GEne in Atherosclerosis
|
||
Completed |
NCT03654313 -
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
|
Phase 1 | |
Completed |
NCT00382564 -
Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease
|
N/A | |
Recruiting |
NCT02894931 -
Effects of Dietary Interventions on Serum and Macrophage Atherogenicity
|
N/A | |
Completed |
NCT02998918 -
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
|
N/A | |
Not yet recruiting |
NCT02578355 -
National Plaque Registry and Database
|
N/A | |
Recruiting |
NCT02265250 -
Pilot Study-Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment
|
||
Completed |
NCT02268513 -
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study
|
||
Completed |
NCT02224339 -
New Technologies to Determine Carotid Plaque Vulnerability
|
||
Completed |
NCT03393377 -
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
|
N/A | |
Completed |
NCT02377310 -
Pd/Pa vs iFRâ„¢ in an Unselected Population Referred for Invasive Angiography
|
N/A | |
Completed |
NCT02116829 -
Is There Room for Butter in a Healthy Diet?
|
N/A |