Clinical Trials Logo

Skull Base Neoplasms clinical trials

View clinical trials related to Skull Base Neoplasms.

Filter by:

NCT ID: NCT04241679 Completed - Clinical trials for Sensorineural Hearing Loss

Auditory Nerve Test System During Vestibular Schwannoma Resection

ANTS
Start date: January 20, 2020
Phase: N/A
Study type: Interventional

The Auditory Nerve Test System (ANTS) is a novel device that stimulates the auditory nerve much like a cochlear implant. The purpose of this study is to demonstrate feasibility of the ANTS during translabyrinthine surgery for vestibular schwannoma resection. If the auditory nerve is kept intact, then the patients will also receive a cochlear implant at the same time potentially alleviating the morbidities caused by a vestibular schwannoma and asymmetric sensorineural hearing loss.

NCT ID: NCT03972514 Active, not recruiting - Brain Tumor Clinical Trials

Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

Start date: March 8, 2019
Phase:
Study type: Observational

This is a prospective, observational clinical trial investigating the morphological and volumetric changes in the brain following cranial Radiation Therapy in pediatric patients with brain or skull base tumors.

NCT ID: NCT03759717 Recruiting - Skull Base Neoplasm Clinical Trials

Molecular and Cellular Characterization of Skull Base Tumors

Start date: October 3, 2018
Phase:
Study type: Observational

The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.

NCT ID: NCT03448614 Active, not recruiting - Clinical trials for Skull Base Neoplasms

Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts

Start date: January 1, 2018
Phase: N/A
Study type: Observational

Endonasal endoscopic approach to the skull base has been expanded in the last several years owing to advances in the radiological aspect that provided a better evaluation of the lesions and the surrounding structures, technological advances that include angled endoscope, development of high-resolution cameras, high definition monitors and navigation systems and better anatomical experience. The endoscopic endonasal approach now provides access to frontal sinus to the second cervical vertebra in the sagittal plane and from the sella to the jugular foramen in the coronal plane. Endoscopic resection of large skull base tumors results in large defect for which repair is a challenge. Several factors besides the size of the defect should be considered during skull base repair as CSF leak, CSF pressure, history or need for future radiotherapy, lack of support and local tissue vascularity. The aim of this study is to Provide an algorithmic approach for skull base reconstruction after endonasal cranio-endoscopic resection using autologous grafts according to the extent of resection, skull base defect size, the presence of CSF leak, CSF pressure and local tissue vascular

NCT ID: NCT03072186 Completed - Neoplasms Clinical Trials

Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery

ICG2
Start date: November 6, 2017
Phase: N/A
Study type: Interventional

This study is being done to demonstrate the feasibility of using a nasal endoscope to perform intraoperative angiography of surgical field, with the goals to evaluate anatomical landmarks and tumor characteristics during skull base surgery and publish a technical note.

NCT ID: NCT02988804 Completed - Clinical trials for Skull Base Neoplasms

Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery

Start date: January 20, 2017
Phase: N/A
Study type: Interventional

The endoscopic endonasal transsphenoidal surgery (EETS) is widely used. Although the incidence of complications is low, hypertensive episodes during surgery and awakening and cerebro spinal fluid (CSF) leakage have been described. The occurrence of coughing or vomiting during the early postoperative period must be avoid to protect the patient from CSF leakage and arterial hypertension. The emergency of anesthesia with laryngeal mask has a better haemodynamic profile and less incidence of cough in some surgical procedures and it could help minimizing the risks after EETS

NCT ID: NCT02117310 Completed - Clinical trials for Skull Base Neoplasms

ICG Use in Angiography for Nasoseptal Flap Harvest

ICG
Start date: March 2015
Phase: N/A
Study type: Interventional

This is a feasibility study in which indocyanine green (ICG) will be administered during routine expanded endonasal approach (EEA) for cranial base pathologies in which a nasoseptal flap harvest will be necessary. The research entails administering ICG, which is already widely used during open neurosurgical procedures, to identify the blood supply at two distinct stages of endonasal cranial base surgery: during nasoseptal flap harvest and after final positioning of the nasoseptal flap to ensure its viability before ending the case.

NCT ID: NCT01228448 Completed - Brain Tumor Clinical Trials

In-Room PET in Proton Radiation Therapy

Start date: October 2010
Phase: N/A
Study type: Interventional

The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation. This allows the participant to be treated and imaged on the same bed. The information obtained may improve the accuracy of treatment and may help to minimize the dose delivered unnecessarily to healthy tissue.