Melanoma Clinical Trial
Official title:
Phase II Trial of Gleevec (Imatinib Mesylate, STI-571) in Metastatic Melanoma
RATIONALE: Imatinib mesylate may interfere with the growth of tumor cells and may be an
effective treatment for metastatic melanoma.
PURPOSE: Phase II trial to study the effectiveness of imatinib mesylate in treating patients
who have metastatic melanoma.
OBJECTIVES:
- Determine the clinical activity of imatinib mesylate (STI571) in patients with
metastatic melanoma.
- Determine the side effects of this drug in these patients.
- Correlate molecular studies with responsiveness to this drug in these patients.
OUTLINE: Patients receive oral imatinib mesylate (STI571) twice daily. Treatment continues in
the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 21-78 patients will be accrued for this study within 6-15
months.
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