Skin Infections Clinical Trial
Official title:
Identification of the Cutaneous Microbiota in Patients With Cutaneous Infection Admitted in the Department of Acute Infectious Diseases
Identify the cutaneous microbiota on a cutaneous lesion (cellulite, wound, rash, etc.) on a swab, biopsies or abscess puncture and on "healthy" skin on a skin swab performed for cutaneous mapping to search for staphylococcal deposits.
Cellulite is characterized by inflammation and an alleged infection of the skin and
subcutaneous tissues. Previous studies have shown a low yield of samples such as biopsy and
needle aspiration of the order of 16%. The most common pathogens are Staphylococcus aureus
and Streptococcus pyogenes.
Conventional cultivation has limitations such as the lack of detection of fastidious
microorganisms, or the use of antibiotics. Molecular diagnostic methods, such as detection of
16S ribosomal DNA followed by amplification and pyrosequencing, have been used to overcome
the limitations of microbial culture.
In a recent study, the authors investigated the causes of acute cellulitis without performing
drainage but skin biopsies from the infected site and another non-infected site by
quantitative PCR, pyrosequencing, and conventional culture. PCR identified
methicillin-resistant S. aureus methicillin in approximately 30% -40% of cases with similar
frequency in infected and uninfected sites. In another study R. felis was found in not only
bedsores, but also, swabs taken from healthy skin, as well as Streptococcus pneumoniae, S.
aureus and Streptococcus group A. Being engaged in the exploration of the human microbiota
especially by culture we propose to extend the knowledge of this skin microbiota in patients
hospitalized in Infectious Disease services.
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