Utility of Trimethoprim-sulfamethoxazole Use in Skin Abscess Management

Status Completed

Clinical Trial Summary

The purpose of this study is to determine if antibiotics are required in the management of skin abscess following incision and drainage.

Clinical Trial Description

This is a double-blind, randomized controlled trial at an urban pediatric emergency department. Sample size (162) was based on a threshold equivalence of 7% (α = 0.05, power = 80%). Inclusion criteria were: non-toxic, immunocompetent, 3 months to 18 years old, English-speaking patients with clinical or ultrasound identified skin abscesses who were not on antibiotics. Patients were block randomized to receive placebo or trimethoprim/sulfamethoxazole following incision and drainage. Follow-up was a call at 2-3 days & a repeat visit or call at 10-14 days. Treatment failure was defined as: persistent erythema, tenderness, and/or draining lesions. New lesion was defined as: primary resolution with development of new lesion (furuncle, carbuncle or abscess) at a different location. Compliance was evaluated by the return of the study medication or by patient report. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00679302
Study type	Interventional
Source	St. Louis University
Contact
Status	Completed
Phase	Phase 4
Start date	July 2006
Completion date	May 2008

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