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Clinical Trial Summary

The main study hypothesis is that Sjögren Disease (SD), usually considered a disorder typical of adult females, may occur not exceptionally in adolescence or even in childhood as a subclinical process. There are several pieces of evidence in favor of this hypothesis, from the incidental detection of asymptomatic SD in pediatric age to biobank-based studies showing that biological signs of SD may precede the disease clinical onset by years or decades. The best scenario to verify this hypothesis could be that of autoimmune thyroiditis, for the following three reasons: 1) subjects with Autoimmune thyroiditis (AT) have a high risk of developing SD (7%); 2) in cases with comorbidity of SD and AT the diagnosis of AT had usually been made before; 3) subjects with AT routinely undergo periodic blood examination and neck ultrasonography (US), which may include Salivary Gland Ultrasound (SGUS) providing contributive data to detect an asymptomatic pre-SD. The knowledge of the real association between AT and pre-SD may impact on several aspects of medicine.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT06324578
Study type Observational
Source IRCCS Burlo Garofolo
Contact Alberto Tommasini, MD PhD Prof
Phone +39.040.3785.422
Email alberto.tommasini@burlo.trieste.it
Status Recruiting
Phase
Start date September 25, 2023
Completion date December 31, 2025