Clinical Trials Logo

Clinical Trial Summary

This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic cell transplantation (HCT) associated with either kidney and/or lung impairment that has not obtained a complete response (CR) or progressed in severity with standard doses of defibrotide.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05987124
Study type Interventional
Source New York Medical College
Contact Mitchell Cairo, MD
Phone 914-594-2150
Email mitchell_cairo@nymc.edu
Status Recruiting
Phase Phase 2
Start date March 20, 2024
Completion date August 1, 2027

See also
  Status Clinical Trial Phase
Completed NCT04141735 - Detection of Sinusoidal Obstruction Syndrome With Ultrasound After Allogeneic HSCT
Completed NCT03858530 - Ultrasound Elastography to Predict Development of SOS Phase 4
Recruiting NCT04313036 - 5-day Defibrotide Treatment for Hepatic SOS/VOD Phase 2
Completed NCT00885950 - Prevention of the Hepatic Sinusoidal Obstruction Syndrome by Means of Anticoagulants N/A
Completed NCT02483481 - Using Ultrasound Elastography to Predict Development of SOS N/A
Not yet recruiting NCT06258525 - SAMe in Prevention of Oxaliplatin-associated Liver Injury Phase 2
Recruiting NCT06054451 - Clinical Diagnosis and Pathological Spectrum of Porto-sinusoidal Vascular Disease in India
Completed NCT03426358 - Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY) N/A
Withdrawn NCT03963999 - Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients Phase 4
Recruiting NCT03865589 - Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome N/A
Completed NCT03132337 - Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study