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Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis — EVmiRNA  

Congenital Heart Disease Clinical Trial

Official title:
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

Clinical Trial Summary

Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not well described. The goal of this proposal is to prospectively collect plasma samples from ten (10) neonates with antenatal diagnosis of severe congenital heart disease (CHD) to better understand mechanisms responsible for abnormal clotting in the perioperative period.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06434207
Study type Observational
Source Boston Children's Hospital
Contact Rachel Bernier, MPH
Phone 857-218-5348
Email rachel.bernier@childrens.harvard.edu
Status Not yet recruiting
Phase
Start date June 1, 2024
Completion date June 1, 2025
View Details
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