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Single Nucleotide Polymorphism clinical trials

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NCT ID: NCT04953533 Recruiting - Gout Clinical Trials

Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout

Start date: July 6, 2021
Phase:
Study type: Observational

To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.

NCT ID: NCT04707612 Completed - Dyslipidemias Clinical Trials

VDR SNPs & 25OHD Correlated With Dyslipidemia

Start date: July 1, 2013
Phase:
Study type: Observational

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

NCT ID: NCT01141829 Recruiting - Oxidative Stress Clinical Trials

NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)

Start date: n/a
Phase: N/A
Study type: Observational

Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related to NADPH oxidase expression or NADPH oxidase activity has been identified. The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA.

NCT ID: NCT00975364 Completed - Clinical trials for Single Nucleotide Polymorphism

Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study

FolGene
Start date: February 2009
Phase: N/A
Study type: Observational

This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.

NCT ID: NCT00819871 Completed - Acute Lung Injury Clinical Trials

Nuclear Factor Kappa-B (NFKB1) Polymorphism and Organ Injury After Cardiac Surgery

Start date: May 2008
Phase: N/A
Study type: Observational

NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.

NCT ID: NCT00665171 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome

Start date: June 2008
Phase: N/A
Study type: Observational

Background: Infertility affects up to 15% of married couples. About half are attributable to female factors, among which anovulation is the leading cause. Some 5% of all women of reproductive age are anovulatory due to the polycystic ovarian syndrome (PCOS). PCOS causes also major health and cosmetic problems and significantly affects quality of life. PCOS is associated with cardiovascular morbidity and Type 2 diabetes mellitus, but it is unclear whether these are caused by the ovarian dysfunction or result from a common denominator. Working hypothesis and aims: Whole genome analysis of multigenerational families in which at least one woman is affected by PCOS may significantly reduce the numbers needed to verify the specific genes, involved in the causation of PCOS. Methods: Registration of multigenerational families and production of personal files with full workup for the presence of PCOS or its absence (in the women participants). Drawing of blood, extraction and preservation of DNA. Analysis of all informative SNPs in the genomes of the participants on a specific microarray chip. Statistical analysis of the results. Expected results: Verification of the loci and putative genes, associated with the appearance of PCOS. Importance: Elucidation of the specific genes underlying the pathology of PCOS. Probable implications to Medicine: Paving the way for targeted treatment of the problems, associated with PCOS, based on the clear knowledge of its underlying cause(s).

NCT ID: NCT00509574 Recruiting - Clinical trials for Single Nucleotide Polymorphism

Association of Genetic Polymorphisms With Lipid Lowering Effects of Statin Therapy

Start date: March 2007
Phase: Phase 4
Study type: Observational

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, also known as statins, played an important role in lipid-lowering therapy and reduction of cardiovascular risks. However, it has been observed that the response to statin therapy varies from patient to patient, and gene polymorphism could have contributed to the variation.