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Single-gene Disorders clinical trials

View clinical trials related to Single-gene Disorders.

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NCT ID: NCT04485598 Completed - Stroke, Acute Clinical Trials

Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel

MDEOS
Start date: August 21, 2015
Phase:
Study type: Observational

The study was designed as a multicenter multiracial prospective observational study of acute ischemic stroke and TIA patients across china. The purpose of this study is to determine the monogenic disorders incidence of Chinese early-onset stroke patients. We plan to consecutively enroll more than 500 patients with early-onset stroke(in the 18- to 45-year age range) admitted in stroke units within 7 days after symptoms onset in participating centers. These early-onset stroke patients are referred for targeted sequencing using 'cerebrovascular disease panel'. By analyzing the sequencing results, we intend to identify monogenic causes causing early-onset stroke and develop clinical algorithms that might assist the clinician in deciding in which early-onset stroke patients testing for monogenic causes of stroke.

NCT ID: NCT01197872 Completed - Clinical trials for Single Gene Disorders

Clinical Use of Parental Support To Detect Single Gene Mutations

Start date: September 2010
Phase: N/A
Study type: Observational

Gene Security Network has developed a novel technology called Parental Support (PS) which is used for Preimplantation Genetic Screening/Diagnosis (PGS/D) during in vitro fertilization (IVF). This technology allows IVF physicians to identify embryos, prior to transfer to the uterus, which have the best chance of developing into healthy children.