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Sickle Cell Disorder clinical trials

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NCT ID: NCT02417298 Terminated - Pain Clinical Trials

Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department

KISS
Start date: November 2015
Phase: N/A
Study type: Interventional

Pain associated with sickle cell disease is a common emergency department visit. It is also frequently associated with a high emergency department recidivism rate for pain control and admissions to the hospital. Opiates are considered the first line therapy for acute flares and to manage chronic pain. This often times leads to a stigma of being "opiate seekers" or "frequent fliers". With this study, we wish to explore whether adding ketamine to standard acute opiate therapy (morphine or dilaudid) will decrease subsequent repeat doses of opiates while improving the patient's perception of pain. In addition, we will be exploring whether ketamine as an adjuvant therapy can help reduce hospital admissions for the management of acute sickle cell crisis pain.