Clinical Study of BRL-101 in the Treatment of Sickle Cell Disease

Status Not yet recruiting

Clinical Trial Summary

This is a single center, non-randomized, open label, single-dose study in subjects with Sickle Cell Disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells (hHSPCs) (BRL-101).

Clinical Trial Description

This clinical trial is a single-arm, single-dose, single center, open-label study without dose escalation. The primary objective is to explore the safety of the study drug in SCD. Myeloablative conditioning and administration for the remaining subjects can only be started after the first subject completes dosing and safety observation and assessment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06287099
Study type	Interventional
Source	Bioray Laboratories
Contact	Xiaoqin Feng, PhD
Phone	020-61641921
Email	fxq126126@126.com
Status	Not yet recruiting
Phase	N/A
Start date	April 20, 2024
Completion date	May 10, 2026

View Details

See also
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