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Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients — Glu_SCD_Egy  

Sickle Cell Disease Clinical Trial

Official title:
Safety and Efficacy of Glutamine in Preventing Vaso-occlusive Crisis Among Sickle Cell Disease Patients: Randomized Controlled Study

Clinical Trial Summary

Prospective phase IV interventional open label randomized controlled trial to assess safety and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and adolescents' patients

Clinical Trial Description

Vaso-occlusive crisis (VOC) episodes are considered to be the cause of 95% of hospitalizations for sickle cell disease (SCD) patients. Prior studies have described pain management in SCD patients with poor outcomes in the short term and decreased quality of life in patients over the long term. Although that L-glutamine has been recently approved by the FDA for the prevention of acute complications in sickle cell disease. However, there are many gaps in our understanding of its therapeutic implications in SCD. This study will assess the safety and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and adolescents' patients ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05371184
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 4
Start date January 4, 2022
Completion date January 7, 2024
View Details
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