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Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA — CRIZ  

Sickle Cell Disease Clinical Trial

Official title:
Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA Novartis Investigator Initiated Trial: CSEG101AUS12T

Clinical Trial Summary

In this prospective, single-arm, open-label, imaging and treatment study, the investigator will test the hypothesis that crizanlizumab will prevent the progression of silent cerebral infarcts in patients with sickle cell disease. Study participants will undergo brain MRI before initiation of crizanlizumab and at 6 and 30 months after starting crizanlizumab infusions. The crizanlizumab cohort will be compared to a matched, observational cohort of patients not receiving crizanlizumab.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05334576
Study type Interventional
Source Washington University School of Medicine
Contact Andria Ford, MD
Phone 314-362-7382
Email forda@wustl.edu
Status Recruiting
Phase N/A
Start date August 1, 2022
Completion date July 1, 2025
View Details
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