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Voxelotor Brain Oxygenation and Neurocognitive Study

Sickle Cell Disease Clinical Trial

Official title:
An Open Label, Single Arm, Multicenter Study to Evaluate the Effect of Voxelotor on Cerebral Blood Flow and Neurocognitive Function in Adolescents and Adults With Sickle Cell Disease

Clinical Trial Summary

This is an open label, single arm multicenter trial to evaluate the effect of voxelotor treatment on cerebral blood flow (CBF) and neurocognitive function in adolescent and young adult participants (12-30 years of age) with sickle cell disease (SCD).

Clinical Trial Description

Eligible participants will receive daily treatment with 1500 mg voxelotor for 24 weeks. During screening, at 12 and 24 weeks, participants will undergo an MRI for evaluation of cerebral blood flow and oxygen extraction fraction as well as NIH toolbox testing for evaluation of executive function, processing speed, and nonexecutive function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05228821
Study type Interventional
Source Pfizer
Contact
Status Withdrawn
Phase Phase 4
Start date August 9, 2023
Completion date August 23, 2023
View Details
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