Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease

Status Recruiting

Clinical Trial Summary

This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older for 12 months. The investigators will enroll 24 patients with SCD over the course of 1 year with a goal to complete all study procedures in 2 years. The short-term goal is to obtain clinical pilot data regarding the safety and efficacy of losartan in stabilizing or decreasing extracellular volume fraction (ECV) after 12 months of therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05012631
Study type	Interventional
Source	Children's Hospital Medical Center, Cincinnati
Contact	Omar Niss, MD
Phone	(513) 803-7545
Email	omar.niss@cchmc.org
Status	Recruiting
Phase	Phase 2
Start date	September 1, 2021
Completion date	December 31, 2024

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