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A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD)

Sickle Cell Disease Clinical Trial

Official title:
An Intrapatient Single Dose and Multiple Ascending Dose Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of GBT021601, a Hemoglobin S Polymerization Inhibitor, in Participants With Sickle Cell Disease (SCD)

Clinical Trial Summary

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK), and pharmacodynamics (i.e., how the body absorbs, distributes, breaks down, and excretes) of GBT021601, a hemoglobin S (HbS) polymerization inhibitor, in participants with SCD, following single and multiple ascending doses.

Clinical Trial Description

This is an open-label intrapatient single dose followed by a multiple dose escalation study in at least six (6) participants with SCD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04983264
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 1
Start date May 21, 2021
Completion date December 6, 2022
View Details
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