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Clinical Trial Summary

This Phase 3 study will assess the safety and efficacy of inclacumab, a P-selectin inhibitor, in reducing the frequency of vaso-occlusive crises (VOCs) in approximately 240 adult and adolescent participants (≥ 12 years of age) with sickle cell disease (SCD). Participants will be randomized to receive inclacumab or placebo.


Clinical Trial Description

Eligible participants will be administered inclacumab or placebo intravenous (IV) every 12 weeks. The total duration of treatment for each participant will be 48 weeks. Participants that complete the study through Week 48 will be provided the opportunity to enroll in an open-label extension (OLE) study. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04935879
Study type Interventional
Source Pfizer
Contact
Status Active, not recruiting
Phase Phase 3
Start date October 26, 2021
Completion date August 15, 2024

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