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Clinical Trial Summary

The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients


Clinical Trial Description

200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, the investigators will perform a training and validation cohort of biologically relevant predictor variables to develop a novel equation. Then the investigators will compare the novel SCA eGFR equation to the established eGFR equation. From one year data, the investigators will determine the longitudinal concordance between pediatric and adult novel and standard eGFR equations with mGFR and variables that may alter longitudinal inferences. In a subset of 30 adult participants, the investigators will also evaluate the correlation between mGFR using iohexol and a novel measure of mGFR that is more time efficient ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04380610
Study type Observational
Source University of Alabama at Birmingham
Contact Jeffrey Lebensburger, DO, MSPH
Phone 205 638-9285
Email jlebensburger@peds.uab.edu
Status Recruiting
Phase
Start date May 12, 2021
Completion date May 15, 2025

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