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A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
A Phase 3 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo With the BB305 Lentiviral Vector in Subjects With Sickle Cell Disease

Clinical Trial Summary

This is a non-randomized, open-label, multi-site, single-dose, Phase 3 study in approximately 35 adults and pediatric subjects ≥2 and ≤50 years of age with sickle cell disease (SCD). The study will evaluate hematopoietic stem cell (HSC) transplantation (HSCT) using bb1111 (also known as LentiGlobin BB305 Drug Product for SCD).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04293185
Study type Interventional
Source bluebird bio
Contact bluebird bio
Phone +1-833-999-6378
Email clinicaltrials@bluebirdbio.com
Status Recruiting
Phase Phase 3
Start date February 14, 2020
Completion date November 2027
View Details
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