Sickle Cell Disease Clinical Trial
Official title:
Retrospective Study of the Risk Factors for Allo-immunization in Sickle Cell Disease
Sickle cell patients have a high prevalence of alloimmunization. This high rate of
alloimmunization can be partially explained by the existence of an antigenic difference
between the predominantly Caucasian donor population and the sickle cell patients of African
origin. Genetic and environmental risk factors have also been described.
The main risk factors that have been shown in retrospective or cross-sectional studies are
some HLA alleles, the age of the patient, the number of leukocyte-depleted erythrocyte
concentrates (CED) transfused, the number of transfusion episodes, the age of the CEDs, the
existence of an inflammatory event at the time of transfusion and the presence of
anti-erythrocyte autoantibodies.There is also evidence of an impaired TH response but the
underlying immunological mechanism is not fully understood.
The aim of this study is to study the prevalence and the risk factors for anti-erythrocyte
alloimmunization in pediatric and adult patients with Sickle Cell Disease (with a SS
genotype) who are being followed at Queen Fabiola University Children's Hospital (HUDERF) and
at the CHU Brugmann Hospital. The identification of risk factors would allow the
investigators to improve, or at least adapt, their transfusion policy to certain clinical or
immuno-haematological situations.
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