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Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration — DREAM²  

Sickle Cell Disease Clinical Trial

Official title:
Determinants of Cerebral Oxygenation and Perfusion in SCA Children Based on Combined ASL MRI, NIRS and Hemorheological Investigation

Clinical Trial Summary

The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.

Clinical Trial Description

The investigators hypothesize that brain perfusion and/or oxygenation modifications may be evidenced in SCA children who have no microarteriopathy and may correlate with hemorheological abnormalities and impaired vasomotion. A multimodal approach designed to study a. cerebral perfusion and oxygenation, b. flow motion properties and c. blood rheological parameters might help to describe the different processes involved in cerebral ischemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02909283
Study type Observational
Source Imagine Institute
Contact
Status Completed
Phase
Start date March 2, 2015
Completion date July 11, 2017
View Details
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