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Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
Propanolol Effect on Red Cell Adhesion in Non-Asthmatic Children With Sickle Cell Disease: A Dose Finding Study

Clinical Trial Summary

Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to upregulate sickle red cell adhesion to laminin and endothelial cells in vitro. The purpose of this pilot study is to administer one dose of propanolol to children with sickle cell disease and to measure pre and post dose red cell adhesion. The hypothesis is that a single dose of propanolol will decrease red cell adhesion to laminin and endothelial cells as compared to baseline.

Clinical Trial Description

A similar pilot study has already been conducted in adults and is now being tried in children to gather preliminary data for a grant submission. No safety issues were found in the adult pilot study. This study will evaluate the effect of different doses of propanolol. The risks of this study involve the risks of three (3) blood draws and the risks of propanolol. In order to minimize the risks children with sickle cell disease and asthma will be excluded because asthma is a contraindication to the use of propanolol. In addition, patients will not be hypertensive or bradycardic. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02012777
Study type Interventional
Source University of Miami
Contact
Status Terminated
Phase Phase 1
Start date June 2010
Completion date April 3, 2013
View Details
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