Sickle Cell Disease Clinical Trial
Official title:
Phase 2 Study of Simvastatin Treatment Effects on Vaso-occlusive Pain in Sickle Cell Disease
The purpose of this study is to determine whether simvastatin is effective in reducing the frequency and intensity of vaso-occlusive pain episodes in patients with sickle cell disease.
Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive episodes and a
chronic inflammatory state leading to progressive multi-organ injury. The pathophysiology of
SCD is related to endothelial dysfunction driven largely by impaired nitric oxide (NO)
homeostasis and chronic inflammation. Through multiple mechanisms, including upregulation of
NO, statins have been shown to confer protection from endothelial injury, independent of
their cholesterol-lowering properties.
By inhibiting inflammation and several common pathways leading to vascular
damage,simvastatin may help prevent the acute and chronic complications of SCD. The
objective of this study is to determine whether our preliminary results showing
simvastatin-associated reductions in plasma markers of vascular injury will translate into a
reduction in vaso-occlusive pain episodes in patients with SCD. A web-based,
smartphone-accessible electronic pain diary will be used to monitor frequency and intensity
of vaso-occlusive pain in SCD patients treated with a single daily dose of simvastatin.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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