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Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease

Sickle Cell Disease Clinical Trial

Official title:
A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease

Clinical Trial Summary

This study will determine if administration of sodium nitrite is safe and can improve small vessel blood flow and tissue oxygenation when given as an additional treatment in patients with acute vaso-occlusive crisis (pain crisis) associated with sickle cell disease.

Clinical Trial Description

Nitric oxide (NO) is a naturally occuring chemical that relaxes blood vessels and helps improve blood flow.

The pain associated with vaso-occlusive crisis (pain crisis) in sickle cell disease is caused in part by lack of oxygen and increased tissue acid because blood flow is blocked by stiff sickle red cells. Administration of sodium nitrite should generate nitric oxide in this area of hypoxia and acidosis and improve blood flow. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01033227
Study type Interventional
Source Children's Hospital Los Angeles
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date December 2009
Completion date June 2012
View Details
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