Sickle Cell Disease Clinical Trial
Official title:
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
Verified date | August 2015 |
Source | HaEmek Medical Center, Israel |
Contact | n/a |
Is FDA regulated | No |
Health authority | Israel: Ministry of Health |
Study type | Observational |
Iron overload impaired growth in Thalassemia patients due to iron deposition in the
endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle
Cell Anemia is recently studied more extensively and preliminary studies shows that
endocrine damage is rarer in those patients.
Growth velocity was not systematically studied in patients with Iron Overload, even in
thalassemia patients in spite several studies that assess the endocrine function in those
patients. In Sickle Cell Patients this issue was not studied.
The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major
and Intermedia patients and compare the results to another group of Sickle Cell patients,
including Sickle cell thalassemia.
Status | Completed |
Enrollment | 93 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 5 Years to 45 Years |
Eligibility |
Inclusion Criteria: - All patients in follow up with available medical charts. Exclusion Criteria: - Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status. |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
Israel | Pediatric Hematology Unit - Ha'Emek Medical Center | Afula |
Lead Sponsor | Collaborator |
---|---|
HaEmek Medical Center, Israel |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia | Analysis of Growth Velocity in Thalassemia and Sickle Cell Anemia and correlation with Iron Overload | One year | No |
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