Sickle Cell Disease Clinical Trial
Official title:
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
Iron overload impaired growth in Thalassemia patients due to iron deposition in the
endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle
Cell Anemia is recently studied more extensively and preliminary studies shows that
endocrine damage is rarer in those patients.
Growth velocity was not systematically studied in patients with Iron Overload, even in
thalassemia patients in spite several studies that assess the endocrine function in those
patients. In Sickle Cell Patients this issue was not studied.
The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major
and Intermedia patients and compare the results to another group of Sickle Cell patients,
including Sickle cell thalassemia.
Growth velocity, endocrine function and iron overload status will be studied in the patients
that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.
Patients who were lost from follow up or insufficient data about growth in the past will not
included in the study.
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Observational Model: Cohort, Time Perspective: Retrospective
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