The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

Sick Sinus Syndrome Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01310920
• Other study ID #: DMR99-IRB-316
• Status: Recruiting
• Phase: N/A
• First received: March 6, 2011
• Last updated: March 8, 2011
• Start date: February 2011

Study information

• Verified date: March 2011
• Source: China Medical University Hospital
• Contact: Jan-Yow Chen, MD
• Phone: +886-4-22062121
• Email: janyow[@]ms77.hinet.net
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• sick sinus syndrome

Exclusion Criteria:

• 1.Severe systemic disease.

• 2.Acute coronary syndrome.

• 3.bradycardia with reversible cause.

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

• Sick Sinus Syndrome

Intervention

Other:
• observation
genotyping

Locations

Country	Name	City	State
Taiwan	China Medical University Hospital	Taiwan

Sponsors (1)

Lead Sponsor	Collaborator
China Medical University Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. Review. — View Citation