Obesity, Childhood Clinical Trial
Official title:
Growth Hormone Secretion Following the Anaerobic Exercise
Proper growth in children is a complex process regulated by a combination of genetic,
nutritional, environmental, hormonal, and others. Growth hormone (GH) is the main hormone
regulating the growth from childhood to adulthood. Despite great progress in the field, with
the development of recombinant GH for the treatment of growth hormone deficiency (GHD), there
is still no reliable method for testing GHD. Physical exertion is one of the significant
physiologic stimuli for GH secretion, and it is reliable test for identification of GHD. It
is not in use in the clinics because of its complexity. Recently GH secretion following short
anaerobic exercise in young adults was tested and also demonstrated significant growth
hormone secretion
In contrast to adult children's exercise is characterized by an anaerobic nature. There is no
data about secretion of growth hormone in response to anaerobic exercise in children.
Purpose of the experiment:
The purpose of this study is to evaluate the secretion of growth hormone in response to
anaerobic exercise in children.
100 children aged 6-16 years, followed at the pediatric endocrinology clinic for growth
assessment or obesity. Assessment of their growth hormone axis will be evaluate in parallel
according to the currently accepted pharmacological GH testing as accepted and also following
anaerobic physical test.
After explanation to the patient and his parent and obtaining an informed consent, the
children will be instructed to pedal at maximum speed for 15 seconds x 10 sprints (1 minute
of recovery between the sprints) against a resistance adjusted according to their body mass
index.
The test will perform in similarity to GH provocative protocols by mean that they will be
performed in the morning after a night's sleep and overnight fasting. The patients will be
remained fasting during the test.
They will be asked not to exercise a day before the test. Thirty minutes before the test,
Venflon will be inserted and the child will receive an explanation and rest until the
beginning of the test. blood GH, IGF-1, cortisol will be taken at the beginning of exercise
(time 0), at the end of exercise, after 30 minutes, 45 minutes and 60 minutes is customary
according to criteria set pharmacological inventory growth hormone.
The test results will be compared to pharmacological testing of the child if available.
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