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Shock clinical trials

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NCT ID: NCT05699005 Recruiting - Anemia Clinical Trials

Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

ICONE
Start date: September 18, 2023
Phase: Phase 1
Study type: Interventional

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock. An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

NCT ID: NCT05697770 Recruiting - Shock Clinical Trials

SODium BICarbonate for Metabolic Acidosis in the ICU

SODa-BIC
Start date: April 26, 2023
Phase: Phase 3
Study type: Interventional

This trial aims to assess if, among adults in the ICU with metabolic acidosis, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days of randomization.

NCT ID: NCT05681052 Recruiting - Septic Shock Clinical Trials

Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients

Start date: October 1, 2022
Phase:
Study type: Observational

Mottling score and central venous oxygen saturation are described as a clinical evaluation of tissue perfusion. This study describes mottling incidence and mottling score in septic shock patients according to central venous oxygen saturation.

NCT ID: NCT05679778 Not yet recruiting - Shock Clinical Trials

PCO2 Gab Marker of Tissue Adequacy of Cardiac Output in Shock State

Start date: January 1, 2023
Phase:
Study type: Observational

1. To assess validity of of central and pulmonary veno - arterial CO2 gradient to predict fluid responsiveness and to guide fluid management and determine the cut off point to continue or stop resuscitation. 2. comparison between PCO2 gab and left ventricular outflow tract velocity time integral to determine whether to continue or stop resuscitation and whether PCO2 gab is a surrogate of cardiac output or not.

NCT ID: NCT05676723 Completed - Clinical trials for Acute Respiratory Distress Syndrome

Thoracic Fluid Content by Bioimpedance-based Starling System

TFC-Bio
Start date: January 18, 2022
Phase:
Study type: Observational

The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax. Thus, TFC may include two of the variables that are commonly used for hemodynamic monitoring: the extravascular lung water (EVLW), and the global end-diastolic volume (GEDV). However, whether the TFC actually reflects GEDV and EVLW has not been clearly established. The objective of the study is to establish the determinants of TFC among hemodynamic variables including EVLW and GEDV.

NCT ID: NCT05664399 Recruiting - Clinical trials for Physiologic Responses to Surprise Events

Shock Factor: Effects of Surprise on Cardiovascular Responses.

Start date: November 24, 2022
Phase:
Study type: Observational

This research will determine the breathing, heart rate and other responses to four surprise events. For two events, virtual reality goggles will be used to create a realistic experience of falling out of a boat and rolling out of a boat or falling of a paddleboard. Two final events will involve falling into a dunk tank with either cool (20℃) or cold (10℃) water.

NCT ID: NCT05661773 Withdrawn - Cardiogenic Shock Clinical Trials

Digital Ischemia Reduction in Critically Ill Patients

DIR
Start date: November 2023
Phase: N/A
Study type: Interventional

Patients requiring high dose pressors (minimum 2) who are unlikely to be weaned off them over 1 day will be identified. Patients will have the device applied to one hand while expectant medical management will continue to the contralateral hand.

NCT ID: NCT05658588 Completed - Septic Shock Clinical Trials

Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock

PedCyto
Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Impact of the hemoadsorption with Cytosorb on hemodynamic in pediatric patients with septic shock: a prospectic pediatric pilot study

NCT ID: NCT05655065 Not yet recruiting - Shock Clinical Trials

Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure

MAPAKI
Start date: January 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.

NCT ID: NCT05649891 Not yet recruiting - Pneumonia Clinical Trials

Checklists Resuscitation Emergency Department

Start date: September 2023
Phase: N/A
Study type: Interventional

The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.