Sexual Orientation Conflict Disorder Clinical Trial
Official title:
Anogenital Distance Differences Between Transgender Males and Female Individuals
This study evaluates the anogenital distance measurement differences between transgender male individuals and normal healthy female individuals. Half of the participants will be selected from the men with a masculine gender identity who were assigned female sex at birth (Woman who wanted to be a man). Transgender men will be evaluated with the vaginal examination, and anogenital distance will be measured at the time of gynecological medico-legal evaluation before the sex reassignment surgery. While the other half of the participants will be selected from healthy female individuals, ordinary healthy women will be selected from patients who come to the gynecology clinic for another reason (Women with normal sexual orientation).
There is considerable evidence in human beings and in animal models supporting that
anogenital distance as a sensitive biomarker of prenatal androgen reflection of reproductive
health and sexual orientation. Anogenital distance is approximately twice as long in male
animals compared to female animals, and it is routinely used to determine the natal or
birth-assigned sex.
Studies have shown alterations in anogenital distance associated with reproductive health and
sexual orientation. For instance, shorter anogenital distance has been reported in boys with
hypospadias and cryptorchidism. Men with reduced testicular volume have significantly shorter
anogenital distance compared with controls. Increased anogenital distance has been indicated
in girls with congenital adrenal hyperplasia.
The investigators hypothesized that a prenatal pathological androgenic environment, resulting
in a longer anogenital distance, will be able to be associated with a higher risk of sexual
orientation disorders like transsexualism. This cross-sectional study aimed to assess the
anogenital distance measurement differences between transgender male persons and normal
healthy female individuals.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04673708 -
H - Test Usage in Identification of Sexual Orientation Among People.
|
N/A |