Clinical Trials Logo

Clinical Trial Summary

Mechanical ventilation will bring many adverse effects. Positive pressure can affect hemodynamics. Inhalation of higher concentrations of oxygen during mechanical ventilation can result in reabsorbed atelectasis for the lungs with a low ventilation-perfusion ratio. Patients who are intubated and mechanically ventilated are at risk for ventilator-associated pneumonia. Mechanical ventilation can induce or aggravate lung injury, called ventilator-induced lung injury (VILI) , Minimizing the duration of mechanical ventilation is the best way to reduce complications. Sevoflurane is a halogen group of inhaled anesthetics commonly used in clinical, with sedation, analgesia, muscle relaxation. Sevoflurane also inhibited respiratory function, tidal volume decreased with the depth of anesthesia, respiratory rate increased, higher than the conscious respiratory rate, but not enough to fully compensate for the decreased tidal volume. The results showed that with the increase of the depth of anesthesia, the minute ventilation decreased, and the ability to remove carbon dioxide also decreased. Based on the background of the study and the pharmacological properties of sevoflurane, we sought to explore the maximum alveolar concentration of sevoflurane for maintaining effective spontaneous respiration in patients, i.e.FiO2 = 30% , PaO2 > 92% , VT > 5 ml/kg, RR > 8/min, PETCO2 < 50 mmHg, sustained > 20s, the time from the beginning of inhalation induction to 1 point OAAS, the changes of hemodynamics during induction, and the recall of induction and operation were also explored.


Clinical Trial Description

Mechanical ventilation is the most widely used short-term life support technique in the world, which can not only provide good condition for anesthesiologists to manage airway, it can also prevent respiratory muscle fatigue and carbon dioxide accumulation caused by insufficient ventilation. At the same time, mechanical ventilation will also bring a lot of adverse effects. Positive pressure ventilation can affect hemodynamics, and studies have shown that high intrathoracic pressure, especially high plateau pressure, can adversely affect right ventricular afterload and function. Inhalation of higher concentrations of oxygen during mechanical ventilation can result in reabsorbed atelectasis for the lungs with a low ventilation-perfusion ratio. Patients who are intubated and mechanically ventilated are at risk for ventilator-associated pneumonia due to low oral and pharyngeal secretions, reduced cough efficiency, and impaired mucociliary clearance. Mechanical ventilation can induce or aggravate lung injury, called ventilator-induced lung injury (VILI) . Minimizing the duration of mechanical ventilation is the best way to reduce complications. Sevoflurane is a halogen group of inhaled anesthetics commonly used in clinical, with sedation, analgesia, muscle relaxation. The blood/gas distribution coefficient is low and the effect is quick. The elimination mainly depends on the lung exhalation, about 5% passes through the liver metabolism, is affected by the anaesthesia time long little. Long-term low-flow sevoflurane inhalation anesthesia has little effect on liver and kidney function. Sevoflurane also inhibited respiratory function, tidal volume decreased with the depth of anesthesia, respiratory rate increased, higher than the conscious respiratory rate, but not enough to fully compensate for the decreased tidal volume. The results showed that with the increase of the depth of anesthesia, the minute ventilation decreased, and the ability to remove carbon dioxide also decreased. Based on the background of the study and the pharmacological properties of sevoflurane, we sought to explore the best alveolar concentration of sevoflurane for maintaining effective spontaneous respiration in patients, i.e. FiO2 = 30% , PaO2 > 92% , VT > 5 ml/kg, RR > 8/min, PETCO2< 50 mmHg, sustained > 20s, the time from the beginning of inhalation induction to 1 point OAAS, the changes of hemodynamics during induction, and the recall of induction and operation were also explored. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05611411
Study type Observational
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact ?? ?
Phone 18359188309
Email 962536345@qq.com
Status Recruiting
Phase
Start date December 1, 2022
Completion date December 6, 2023

See also
  Status Clinical Trial Phase
Completed NCT06018597 - The Relationship of Sevoflurane Consumption With Metabolic Age
Completed NCT01219881 - Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery Phase 3
Completed NCT01096212 - Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia Phase 4
Enrolling by invitation NCT05011214 - Comparison of Sedation by Esketamine and Sevoflurane Phase 4
Recruiting NCT06210061 - Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring N/A
Completed NCT05554263 - Comparison of Automated Control Anesthesia and Manual Control Anesthesia in Minimal Flow Anesthesia
Completed NCT00949507 - Comparison of Two Regimens of Anesthesia for Children Undergoing Magnetic Resonance Imaging (MRI) in General Anesthesia Phase 4
Completed NCT03003377 - Sevoflurane-remifentanil EC50 (The 50% Effective Concentration) Values for LMA-Supreme Versus LMA ProSeal Insertion Phase 4
Not yet recruiting NCT06386965 - Sevoflurane Versus Propofol: Effect on Stress Response
Completed NCT01285271 - A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon Phase 3
Completed NCT04123249 - The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep N/A
Completed NCT06375863 - QT Changes in Geriatric Patients: a Comparison of Spinal and General Anesthesia N/A
Completed NCT01662622 - Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram Phase 4
Recruiting NCT06396468 - Sevoflurane and Intravenous Anesthesia in Hypospadias Repair N/A
Completed NCT04292561 - Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia N/A
Recruiting NCT04950205 - Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped Early Phase 1
Completed NCT01231477 - Cytokines and Sevoflurane During Surgery N/A
Completed NCT04431557 - The Electroencephalogram Analysis in the Differences Between Inhalation Anesthetic and Propofol.
Enrolling by invitation NCT03595163 - Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children N/A
Enrolling by invitation NCT03522402 - Effect of Head Position on MACEI of Sevoflurane in Children With Obstructive Airway N/A