Severe Upper Limb Tremor Refractory to Medical Therapy Clinical Trial
Official title:
Deep Brain Stimulation and Frameless Stereotactic Radiosurgery in the Treatment of Drug Resistant Invalidating Tremor
Stereotactic lesioning of thalamus and basal ganglia for treatment of tremor is a well-known
procedure which, prior to the introduction of deep brain stimulation, or DBS, was usually
achieved using stereotactic surgical procedures.
Radiosurgery of invisible targets to treat movement disorders and intractable pain are still
the domain of frame-based procedures, due to the need of a solid reference system registered
to the anterior commissure-posterior commissure (AC-PC) line, which allows the use of
stereotactic atlases.
In this study we want to utilize a mathematical method that uses atlas-derived stereotactic
coordinates to perform frameless images-guided radiosurgery of such functional targets
Particularly the aim of the present study is to investigate both the efficacy and the safety
of the methodology to treat upper limb and hand tremor in elderly or in patients which are
not ot susceptible of surgical procedures. For these reasons a dose escalation prospective
trial have been designed.
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