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Canadian Hemophilia Prophylaxis Study — CHPS  

Severe Hemophilia A Clinical Trial

Official title:
Moderate Term Musculoskeletal Outcomes With Escalating Dose Prophylaxis: the Canadian Hemophilia Prophylaxis Study Follow-up Study

Clinical Trial Summary

Primary prophylaxis given less frequently initially, with the infusion frequency increased if needed (Escalating Dose Prophylaxis), is likely to be less expensive and associated with fewer complications than standard prophylaxis while reducing disability to a greater degree than intermittent therapy.

Clinical Trial Description

There are 2 specific study objectives. The first is to estimate the incidence of target joint bleeding in patients with severe hemophilia A treated (for primary prophylaxis) with Escalating Dose Prophylactic factor replacement. The second objective is to obtain accurate estimates of the direct and indirect costs associated with this protocol for use in a cost-effectiveness model (comparing Escalating Dose with standard prophylaxis and with intermittent therapy). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01085344
Study type Interventional
Source The Hospital for Sick Children
Contact
Status Completed
Phase Phase 4
Start date June 26, 1997
Completion date December 2014
View Details
See also
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