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Severe Burns clinical trials

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NCT ID: NCT03118362 Completed - Fluid Resuscitation Clinical Trials

Fluid Resuscitation in Burn Patients

CARE
Start date: August 9, 2017
Phase: Phase 3
Study type: Interventional

Balanced solutions with low chloride concentration could represent an alternative to high chloride concentration solutions. Such balanced solutions contain other acid as buffers (i.e. acetate and/or gluconate). However, acetate has been associated with alteration of cardiac function when used as buffer in dialysate when high acetate concentrations are used and could promote the development of metabolic acidosis if it accumulates. Therefore, the safety of such solutions remains poorly explored. Because critically ill patients receive large amount of fluid during the early phase of resuscitation, large amount of acetate are to be administrated if such solutions are used. While acetate-containing solutions have been suggested to be safe in this setting, studies are still lacking regarding clearance and accumulation in critically ill patients. It is expected to include 28 patients, the objective to analyze the data of 20 patients.

NCT ID: NCT00236093 Completed - Pain Clinical Trials

Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain

Start date: October 2006
Phase: Phase 2
Study type: Interventional

The objective of the study is to monitor the safety (adverse event data) of longer-term use of ACTIQ (Oral Transmucosal Fentanyl Citrate [OTFC]) treatment in children with pain associated with cancer, sickle cell disease, or severe burns and breakthrough pain (BTP) who are receiving around the clock (ATC) opioid therapy.