Clinical Trials Logo
  1. Home
  2. Severe Aortic Stenosis
  3. NCT03291925

Primary Non-invasive Cardiac Computed Tomography Versus Routine Invasive Angiography Prior to TAVI — CT-CA  

Transcatheter Aortic Valve Implantation Clinical Trial

Official title:
Primary Non-invasive Cardiac Computed Tomography Versus Routine Invasive Angiography Prior to TAVI: A Randomized Controlled Pilot Trial (CT-CA Study)

Clinical Trial Summary

This pilot study is a prospective, randomized, open-label trial that aims to assess the feasibility of comparing a primary Computed tomography/Cardiac computed tomography angiography (CT/CCTA) strategy (test arm) to a strategy combining routine use of CT/CCTA and invasive CA (control arm) prior to a Transcatheter aortic valve implantation (TAVI) procedure. The study will also estimate the rate of composite coronary adverse events (myocardial infarction, post procedural coronary revascularization and cardiovascular mortality) between the two arms at 90 days follow-up. The primary endpoint will be the feasibility of recruitment and compliance with the study protocol at 2 sites in Canada and 1 site in Denmark. Additional clinical endpoints including: all-cause death at 90 days post procedure, myocardial infarction at 90 days post procedure, unplanned PCI or CABG at 90 days post procedure, stroke at 90 days post procedure, CA and PCI related cumulative vascular complications events. This information will be used to inform the design of the definitive efficacy trial.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03291925
Study type Interventional
Source BC Centre for Improved Cardiovascular Health
Contact Shirley Wong, PhD
Phone 604-682-2344
Email 3M@icvhealth.ubc.ca
Status Recruiting
Phase N/A
Start date November 2016
Completion date September 2019
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05808907 - Patient Reported Outcomes (PROMs) in Transcatheter Aortic Valve Implantation (TAVI) Patients
Recruiting NCT05133843 - Complete Functional Assessment of Intermediate Coronary Artery Stenosis Before and After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Symptomatic Aortic Valve Stenosis N/A
Completed NCT02976792 - Effectiveness of the NephroCheck™ After TAVI
Enrolling by invitation NCT06212050 - Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis
Completed NCT04482816 - Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post-TAVI N/A
Not yet recruiting NCT05528211 - Safety and Efficacy of Emergent TAVI in Patients With Severe AS
Recruiting NCT06197503 - Randomized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI N/A
Recruiting NCT05804903 - Investigation of the NVT ALLEGRA Plus THV System in Patients With Severe Aortic Stenosis or Failed Surgical Aortic Bioprosthesis N/A
Recruiting NCT05217888 - The Sentinel Registry
Recruiting NCT05491070 - Comparison of Different Vascular Closure Device in TAVI N/A
Recruiting NCT06189976 - Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation N/A
Completed NCT04921475 - Renal Regional Oxygen Saturation During Transcatheter Aortic Valve Implantation
Completed NCT03966417 - Exercise Training After Transcatheter Aortic Valve Implantation N/A
Not yet recruiting NCT05895097 - Conventional Versus Left Bundle Branch Pacing in TAVI N/A
Recruiting NCT04443023 - Comparison of Eligible TAVI-valves - Cohort B N/A
Not yet recruiting NCT05422170 - HEParin Antagonisation in Transcatheter Aortic Valve Implantation
Completed NCT01539746 - Transcatheter Aortic Valve Implantation Without Predilation N/A
Recruiting NCT05478161 - Investigation of the ALLEGRA THV System With a New Delivery System in Patients With Aortic Stenosis or Failed Surgical Bioprosthesis N/A
Recruiting NCT02659137 - HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients N/A
Completed NCT02224066 - Platelet Reactivity After TAVI: A Multicenter Pilot Study Phase 4