Severe Acute Malnutrition Clinical Trial
Official title:
Assessing the Risk of Hospital-acquired Infection and Multi-drug Resistance Among Hospitalized Severe Acutely Malnourished Children
While the standardization of treatment protocols for Severe Acute Malnutrition (SAM) has
helped to reduce historically high mortality, mortality in inpatient settings remains
substantial, likely due to the severity of complications associated with late presentation
and health-care associated infection (HCAI).
The purpose of this study is to serve as an important stand-alone description to inform the
understanding of the magnitude of the problem and help guide implementation of measures to
reduce the risk of nosocomial infection and multi-drug resistance.
This study is designed as a cross-sectional, non-randomized, two-site, four-phase study: an
initial baseline period, two intervention periods, and a final interruption period.
This is a descriptive study to collect information on the risk of HCAIs in the MSF-supported
inpatient nutritional treatment centers. Information on key clinical indicators will be
collected regularly according to the routine program procedures from the time of admission to
discharge. All children will undergo a blood draw for culture at time of admission and at the
time of any suspected hospital-acquired bloodstream infection. As part of active surveillance
for bacterial colonization, including multi-drug resistant organisms, all children will
undergo nasal and rectal swabs at the time of admission, suspected infection, and discharge.
Data will provide an estimate of nosocomial infection incidence under routine circumstances
and inform sample size calculations if further study is warranted.
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