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Septic Shock clinical trials

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NCT ID: NCT06217562 Enrolling by invitation - Septic Shock Clinical Trials

Vasopressin for Septic Shock Pragmatic Trial

VASSPR
Start date: February 1, 2024
Phase: Phase 4
Study type: Interventional

Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure. Sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. However, the threshold at which to start vasopressin remains unclear. This pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.

NCT ID: NCT05900284 Enrolling by invitation - Sepsis Clinical Trials

Safety and Feasibility of Metformin for Sepsis Induced AKI

Start date: November 8, 2023
Phase: Phase 2
Study type: Interventional

Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit. Sepsis is the most frequent cause of AKI, affecting 48 million people worldwide every year, and accounting for approximately 11 million of annual global deaths. Despite these figures, there are no known therapies to prevent or reverse septic AKI; hence this study aims to establish the safety and feasibility of the implementation of metformin in the treatment of AKI in patients with sepsis. This study is the first critical step to inform the design of a future, full-scale efficacy randomized clinical trial.

NCT ID: NCT05602584 Enrolling by invitation - Sepsis Clinical Trials

Effect of Immunophenotype on Prognosis of Sepsis

Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

The popuse of this study is to assess the inflammatory immunophenotypes of sepsis patients are significantly correlated with prognosis, which may provide theoretical basis for precise immune regulation of sepsis.