Sepsis Clinical Trial
Official title:
Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness
This study aims to investigate how sepsis and shock can impair microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.
This longitudinal study will assess microvascular function through four (4) follow-ups after ICU discharge: at (i) 7 days, (ii) 3 months, (iii) 6 months, and (iv) 12 months. The goal is to understand how microvascular dysfunction contributes to ICU-AW and long-term exercise limitation in ICU survivors. Specific goals are: 1. Characterize the natural trajectory of skeletal muscle microvascular function in ICU survivors using high-resolution NIRS. 2. Demonstrate an impairment in skeletal muscle microvascular oxygen delivery and cardiovascular blood flow regulation in ICU survivors. ;
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