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To Develop an Algorithm for Predicting the Unfavorable Course of Sepsis in Children Based on a Comprehensive Assessment of Immunological, Biochemical and Molecular Genetic Markers

Sepsis Clinical Trial

Official title:
To Develop an Algorithm for Predicting the Unfavorable Course of Sepsis in Children Based on a Comprehensive Assessment of Immunological, Biochemical and Molecular Genetic Markers

Clinical Trial Summary

Current study evaluates the relationship between cell immunity, biochemical and genetic markers in patients with sepsis in order to develop algorithm for predicting the course and outcome of severe bacterial infections.

Clinical Trial Description

- To study the state of the immune system in patients with sepsis: the content of blood monocyte subpopulations (classical, intermediate and non-classical monocytes), HLA-DR expression on monocytes, CD64 expression on neutrophils, spontaneous and stimulated production of reactive oxygen species by blood neutrophils etc.; - To study biochemical blood parameters and genetic polymorphism of immune response genes; - To evaluate the relationship between genetic features of the patient's immune system, biochemical blood parameters, immune system cells and the severity of the pathological process. - To develop an algorithm to prevent the development of sepsis in children. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06142162
Study type Observational
Source The Republican Research and Practical Center for Epidemiology and Microbiology
Contact Elena G Fomina, Dr
Phone +375173430417
Email feg1@tut.by
Status Recruiting
Phase
Start date July 1, 2021
Completion date June 30, 2024
View Details
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