Sepsis Clinical Trial
Official title:
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients. The central hypothesis is that a threshold burden of SnCs predisposes to a SASP mediated dysfunctional response to PAMPs, contributing to a disproportionate burden of sepsis in older patients. The study hypothesizes timely treatment with fisetin will interrupt this pathway. A multicenter, randomized, adaptive allocation clinical trial to identify the most efficacious dose of the senolytic fisetin to reduce the composite cardiovascular, respiratory, and renal sequential organ failure assessment score at 1 week, and predict the probability of success of a definitive phase III clinical trial.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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Phase 3 | |
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| Completed |
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Phase 3 | |
| Completed |
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| Recruiting |
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N/A | |
| Terminated |
NCT04117568 -
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| Completed |
NCT03550794 -
Thiamine as a Renal Protective Agent in Septic Shock
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Phase 2 | |
| Completed |
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Evaluation of Infection in Obstructing Urolithiasis
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| Completed |
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N/A | |
| Enrolling by invitation |
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| Terminated |
NCT03335124 -
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
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Phase 4 | |
| Recruiting |
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Machine Learning Sepsis Alert Notification Using Clinical Data
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Phase 2 | |
| Completed |
NCT03258684 -
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
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N/A | |
| Recruiting |
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Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
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| Completed |
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Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery
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N/A | |
| Completed |
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N/A | |
| Not yet recruiting |
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| Not yet recruiting |
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N/A | |
| Not yet recruiting |
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Phase 3 |