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NCT05410665 Clinical Trial

The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis

Sepsis Clinical Trial

Official title:
The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05410665
Other study ID # YKK21134
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 31, 2022
Est. completion date June 30, 2024

Study information
Verified date June 2022
Source Nanjing First Hospital, Nanjing Medical University
Contact Jie Zhou, Dr.
Phone +8613913893984
Email 565219791@qq.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date June 30, 2024
Est. primary completion date December 31, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: 1. Clinical diagnosis of sepsis 2. Within 3 days of sepsis onset before ICU admission 3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission Exclusion Criteria: 1. Ileus 2. Digestive tract hemorrhage 3. Inflammatory bowel disease 4. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction) 5. Malnutrition or immunodeficiency 6. Long-term use of hormones

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Standard treatments for sepsis
Standard treatments for others

Locations
Country Name City State
China Nanjing First Hospital Nanjing Jiangsu

Sponsors (1)
Lead Sponsor Collaborator
Nanjing First Hospital, Nanjing Medical University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Incidence of intestinal barrier injury incidence of intestinal barrier injury intestinal barrier injury 7 days
Secondary Incidence of ferroptosis ferroptosis 7 days
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