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Clinical Trial Summary

Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the most common pathogens associated with multidrug resistance and HAIs. These bacteria are of special concern because few therapeutic options are available. Traditionally, the duration of treatment for severe multidrug-resistant (MDR)-GNB infections is 14 days. Studies of severe infections by GNB, regardless of susceptibility profile, have shown that shorter antimicrobial treatments are not inferior to traditional durations of therapy and are associated with a lower incidence of adverse effects. However, there are currently no studies assessing whether shorter duration of antimicrobial treatment is effective for MDR-GNB. This open-label, randomized clinical trial aims to assess the non-inferiority of 7-day antibiotic therapy compared to conventional 14-day treatment in severe infections by MDR-GNB.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05210387
Study type Interventional
Source Hospital Moinhos de Vento
Contact Alexandre Prehn Zavascki
Phone +55 51 99714-9578
Email [email protected]
Status Recruiting
Phase N/A
Start date January 27, 2022
Completion date December 31, 2023

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