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HAT for the Treatment of Sepsis Associated With NASTI

Sepsis Clinical Trial

Official title:
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis Associated With Acute Necrotizing Soft Tissue Infections, The NASTI HAT Trial

Clinical Trial Summary

Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.

Clinical Trial Description

Primary outcome: 1. Hospital survival Secondary outcomes: 1. Duration of vasopressor therapy 2. Requirement for renal replacement therapy in patients with Acute Kidney Injury (AKI) 3. ICU length of stay (LOS) 4. Change in serum procalcitonin (PCT) over first 72 hours 5. Change in SOFA score over first 72 hours (measured as SOFA score daily for four days, with day one being admission, then 3 days after, totaling 4 days of treatment with HAT) 6. Procalcitonin clearance (formula = initial PCT - 72 hour PCT divided by initial PCT x 100) 7. Number of wound related surgeries 8. Wound status at time of hospital discharge: 1. Open 2. Closed ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05157360
Study type Interventional
Source Ascension Via Christi Hospitals Wichita, Inc.
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date September 10, 2021
Completion date May 16, 2023
View Details
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