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Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome

Sepsis Clinical Trial

Official title:
Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome in Mechanically Ventilated Patients With Sepsis in Intensive Care Unit

Clinical Trial Summary

This study aims to assess whether the degree of diaphragm excursion and diaphragm thickening measured by ultrasound during a weaning trial may be used to predict successful weaning from mechanical ventilation in patients with sepsis in intensive care unit

Clinical Trial Description

After being informed about the study and giving written informed consent, Intubated and mechanically ventilated patients with sepsis on admission and fulfilling criteria of weaning from mechanical ventilation (MV), will undergo diaphragm ultrasound during spontaneous breathing trial on T-piece. We will measure diaphragm excursion (DE), diaphragm thickness (DT) and calculate diaphragm thickness fraction (DTF): DT during inspiration - DT during expiration / DT during expiration According to weaning outcome, patients will be divided into 2 groups: - Successful weaning group - Weaning failure group By statistical analysis we will define the cut off value and area under curve (AUC) for DE and DTF and we can confirm if DE and DTF using ultrasound can be used as predictors for weaning from MV or not ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04825509
Study type Observational [Patient Registry]
Source Ain Shams University
Contact
Status Completed
Phase
Start date April 18, 2021
Completion date November 1, 2021
View Details
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