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INFLAmmasomes NLRP3 in Platelets and Leukocytes During SEPSIS in Intensive Care Unit — INFLA-SEPSIS  

Sepsis Clinical Trial

Official title:
Study of INFLAmmasomes NLRP3 in Platelets and Leukocytes During SEPSIS in Intensive Care Unit (INFLA-SEPSIS)

Clinical Trial Summary

septic shock is the first cause of mortality in intensive care unit. Innate immunity is the body's first line of defense against pathogens

Clinical Trial Description

since their discovery, inflammasomes have an important role during inflammatory response following an aggression. There are intracytoplasmic multiprotein complex activated by cellular stress or infections and is responsible for the release of pro-inflammatory cytokines, including IL-1β. One study focused on the role of the NLRP3 inflammasome in monocyte during sepsis has shown its early alteration that is correlated with mortality. Most studies have analysed inflammasomes in nucleated cells, nevertheless, little is known about inflammasomes in platelets. The aim of the study is to analyze the activation of NLRP3 inflammasome in platelets and leukocytes during sepsis, from patients hospitalized in intensive care unit compare to a control group, until its resolution to better understand the pathophysiology of sepsis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04635878
Study type Observational
Source University Hospital, Toulouse
Contact Fanny BOUNES, PH
Phone 05 61 32 27 99
Email Bounes.f@chu-toulouse.fr
Status Recruiting
Phase
Start date July 27, 2020
Completion date July 2022
View Details
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